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CAS No: 1211327-92-2
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Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS).
体内研究：
Peginterferon beta-1a (0.1-1.6 mg/kg; s.c. QW/BIW/TIW for 3-4 weeks) inhibits SK-MEL-1, A-375 melanoma and WM-266-4 melanoma cancer growth in xenografts nude mice.Animal Model:Nude mice with human SK-MEL-1 and A-375 melanoma xenografts
Dosage:0.1-1.6 mg/kg
Administration:Subcutaneous injection; once/twice a week; for 3/4 weeks
Result:Significantly inhibited SK-MEL-1 tumor growth at 0.4 mg/kg (QW; 3 w) and inhibited A-375 melanoma tumors at 1.6 mg/kg (BIW; 4 w).
Animal Model:Nude mice with human WM-266-4 melanoma xenografts
Dosage:0.4-1.6 mg/kg
Administration:Subcutaneous injection; 0.4-1.6 mg/kg; once/twice/three times a week for 4 w
Result:The QW dose of 1.6 mg/kg and all doses given BIW and TIW induced tumor regression, with a 1.6 mg/kg QW dose induced significant tumor inhibition relative to 0.8 mg/kg QW.
体外研究：
Peginterferon beta-1a (0.001-1000 ng/mL; 5 d) affects cell viability of SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cells.Peginterferon beta-1a (10, 100, and 1,000 ng/mL) induces cell apoptosis.
Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS).
体内研究：
Peginterferon beta-1a (0.1-1.6 mg/kg; s.c. QW/BIW/TIW for 3-4 weeks) inhibits SK-MEL-1, A-375 melanoma and WM-266-4 melanoma cancer growth in xenografts nude mice.Animal Model:Nude mice with human SK-MEL-1 and A-375 melanoma xenografts
Dosage:0.1-1.6 mg/kg
Administration:Subcutaneous injection; once/twice a week; for 3/4 weeks
Result:Significantly inhibited SK-MEL-1 tumor growth at 0.4 mg/kg (QW; 3 w) and inhibited A-375 melanoma tumors at 1.6 mg/kg (BIW; 4 w).
Animal Model:Nude mice with human WM-266-4 melanoma xenografts
Dosage:0.4-1.6 mg/kg
Administration:Subcutaneous injection; 0.4-1.6 mg/kg; once/twice/three times a week for 4 w
Result:The QW dose of 1.6 mg/kg and all doses given BIW and TIW induced tumor regression, with a 1.6 mg/kg QW dose induced significant tumor inhibition relative to 0.8 mg/kg QW.
体外研究：
Peginterferon beta-1a (0.001-1000 ng/mL; 5 d) affects cell viability of SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cells.Peginterferon beta-1a (10, 100, and 1,000 ng/mL) induces cell apoptosis.
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