产品
编 号：F743373
分子式：C14H10O5
分子量：258.23
分子式：C14H10O5
分子量：258.23
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规格
价格
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结构图
CAS No: 123297-90-5
产品详情
生物活性：
STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3.
体外研究：
STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3. STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50 values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively.
STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3.
体外研究：
STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3. STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50 values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively.
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