产品
编 号：F743328
分子式：C29H23ClN4O4
分子量：526.97
分子式：C29H23ClN4O4
分子量：526.97
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 1227961-59-2
产品详情
生物活性：
Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).
体内研究：
Seco-DUBA (89 μg/kg; i.v.) is likely converted to DUBA almost instantaneously.Animal Model:Wistar rats
Dosage:89 μg/kg (Pharmacokinetic Analysis)
Administration:I.v.
Result:Likely converted to DUBA almost instantaneously.
体外研究：
Seco-DUBA (SK-BR-3 cells; 0.0001 pM~0.01 nM; 144 hours) dose-dependent reduces cell viability and shows equally potent and efficacious as DUBA.Seco-DUBA causes SK-BR-3 (IC50=0.09), SK-OV-3 (IC50=0.43), and SW620 (IC50=0.09) cells to exhibit highly sensitive.
Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).
体内研究：
Seco-DUBA (89 μg/kg; i.v.) is likely converted to DUBA almost instantaneously.Animal Model:Wistar rats
Dosage:89 μg/kg (Pharmacokinetic Analysis)
Administration:I.v.
Result:Likely converted to DUBA almost instantaneously.
体外研究：
Seco-DUBA (SK-BR-3 cells; 0.0001 pM~0.01 nM; 144 hours) dose-dependent reduces cell viability and shows equally potent and efficacious as DUBA.Seco-DUBA causes SK-BR-3 (IC50=0.09), SK-OV-3 (IC50=0.43), and SW620 (IC50=0.09) cells to exhibit highly sensitive.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备