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编 号：F743325
分子式：C11H13F2NO
分子量：213.22
分子式：C11H13F2NO
分子量：213.22
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CAS No: 1227638-29-0
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生物活性：
Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease.
体内研究：
IRL752 (3.7-100 μmol/kg, s.c.) has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reversed deficits resulting from hypomonoaminergic function.Animal Model:Normal rats.
Dosage:3.7-100 μmol/kg.
Administration:s.c., 30 min prior to testing.
Result:Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.
体外研究：
IRL752 displayed its highest in vitro affinities for 5-HT and NA-related targets.
Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease.
体内研究：
IRL752 (3.7-100 μmol/kg, s.c.) has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reversed deficits resulting from hypomonoaminergic function.Animal Model:Normal rats.
Dosage:3.7-100 μmol/kg.
Administration:s.c., 30 min prior to testing.
Result:Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.
体外研究：
IRL752 displayed its highest in vitro affinities for 5-HT and NA-related targets.
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