产品
编 号：F743254
分子式：C34H36N6O4
分子量：592.69
分子式：C34H36N6O4
分子量：592.69
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1220626-82-3
产品详情
生物活性：
JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma.
体内研究：
JNJ-49095397 (RV568) (1-20 μg/mouse; intratracheal; once) 在 LPS 诱导的中性粒细胞积累小鼠模型中显示出抗炎活性。Animal Model:Nonfasted Balb/c mice, LPS-induced neutrophil accumulation model
Dosage:1, 4 and 20 μg/mouse
Administration:Intratracheal administration, 2, 8 or 12 h prior to LPS inhalation
Result:Prevented the accumulation of neutrophils in the BAL fluid. Significantly inhibited neutrophil accumulation when administered up to 8 h prior to LPS inhalation.
体外研究：
JNJ-49095397 (RV568) (1 pg-1 μg/mL;4 h) 在 PBMCs 和 d-U937 细胞中抑制 LPS 诱导的 CXCL8 释放。JNJ-49095397 (1 μg-1 g/mL; 4 h) 以浓度依赖的方式抑制 TNFα 诱导的白细胞介素 (IL)-6 和 CXCL8 的释放。
JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma.
体内研究：
JNJ-49095397 (RV568) (1-20 μg/mouse; intratracheal; once) 在 LPS 诱导的中性粒细胞积累小鼠模型中显示出抗炎活性。Animal Model:Nonfasted Balb/c mice, LPS-induced neutrophil accumulation model
Dosage:1, 4 and 20 μg/mouse
Administration:Intratracheal administration, 2, 8 or 12 h prior to LPS inhalation
Result:Prevented the accumulation of neutrophils in the BAL fluid. Significantly inhibited neutrophil accumulation when administered up to 8 h prior to LPS inhalation.
体外研究：
JNJ-49095397 (RV568) (1 pg-1 μg/mL;4 h) 在 PBMCs 和 d-U937 细胞中抑制 LPS 诱导的 CXCL8 释放。JNJ-49095397 (1 μg-1 g/mL; 4 h) 以浓度依赖的方式抑制 TNFα 诱导的白细胞介素 (IL)-6 和 CXCL8 的释放。
产品资料
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