产品
编 号：F072101
分子式：C11H15N5O5
分子量：297.27
分子式：C11H15N5O5
分子量：297.27
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
456
In-stock
5mg
1002
In-stock
10mg
1887
In-stock
50mg
5720
In-stock
结构图
CAS No: 121032-29-9
产品详情
生物活性：
Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL).
体内研究：
Nelarabine (506U78) (130 mg/kg/day; i.v.; 5 days) reduces leukemic burden and extends mouse survival in NSG mice xenografted with luciferase-expressing U937 cells.Animal Model:NSG mice xenografted with luciferase-expressing U937 cells
Dosage:130 mg/kg/day
Administration:Intravenous injection, 5 days
Result:Reduced leukemic burden and extended mouse survival.
体外研究：
Nelarabine (506U78) (0-20 μM; 48 h) induces cytotoxic effects in T-ALL cell lines.Nelarabine (5 or 2 μM; 48 h) promotes apoptosis in sensitive T-ALL cell lines and modulates PI3K/AKT/mTOR and MEK signaling.Nelarabine (10 μM; 0-48 h) resistance does not depend on expression of ENT1/2 transporters and is partly due to upregulation of PI3K, MEK, and Bcl2 signaling.
Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL).
体内研究：
Nelarabine (506U78) (130 mg/kg/day; i.v.; 5 days) reduces leukemic burden and extends mouse survival in NSG mice xenografted with luciferase-expressing U937 cells.Animal Model:NSG mice xenografted with luciferase-expressing U937 cells
Dosage:130 mg/kg/day
Administration:Intravenous injection, 5 days
Result:Reduced leukemic burden and extended mouse survival.
体外研究：
Nelarabine (506U78) (0-20 μM; 48 h) induces cytotoxic effects in T-ALL cell lines.Nelarabine (5 or 2 μM; 48 h) promotes apoptosis in sensitive T-ALL cell lines and modulates PI3K/AKT/mTOR and MEK signaling.Nelarabine (10 μM; 0-48 h) resistance does not depend on expression of ENT1/2 transporters and is partly due to upregulation of PI3K, MEK, and Bcl2 signaling.
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