产品
编 号：F743140
分子式：C15H13NO3
分子量：255.27
分子式：C15H13NO3
分子量：255.27
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1208448-95-6
产品详情
生物活性：
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research.
体内研究：
MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice.Animal Model:Hypoxic male C57BL/6J mice
Dosage:40 mg/kg
Administration:Intraperitoneal injection; once a day; 4 weeks
Result:Reduced right ventricular systolic pressure (RVSP), percentage medial wall thickness, muscularization and right ventricle collagen deposition.Decreased percentage of collagen fibers in pulmonary artery (PA).
体外研究：
MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration in a concentration-dependent manner, by blocking the migration inhibitory factor (MIF) pathway.MIF098 reduces collagen synthesis and pulmonary artery fibrosis by inhibiting the TGFβ1/Smad2/3 pathway.
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research.
体内研究：
MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice.Animal Model:Hypoxic male C57BL/6J mice
Dosage:40 mg/kg
Administration:Intraperitoneal injection; once a day; 4 weeks
Result:Reduced right ventricular systolic pressure (RVSP), percentage medial wall thickness, muscularization and right ventricle collagen deposition.Decreased percentage of collagen fibers in pulmonary artery (PA).
体外研究：
MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration in a concentration-dependent manner, by blocking the migration inhibitory factor (MIF) pathway.MIF098 reduces collagen synthesis and pulmonary artery fibrosis by inhibiting the TGFβ1/Smad2/3 pathway.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备