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编 号：F743069
分子量：9345
分子量：9345
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CAS No: 1198621-85-0
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生物活性：
ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'.
体内研究：
ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth.Animal Model:Female BALB/c mice (6-8 weeks; inoculated with 5×105 EMT6 cells)
Dosage:25 μg per mouse
Administration:Peritumoral injection, six times in one-day interval, for 0-100 days
Result:Induced significant inhibition of tumor growth.
体外研究：
ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL.ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells.
ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'.
体内研究：
ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth.Animal Model:Female BALB/c mice (6-8 weeks; inoculated with 5×105 EMT6 cells)
Dosage:25 μg per mouse
Administration:Peritumoral injection, six times in one-day interval, for 0-100 days
Result:Induced significant inhibition of tumor growth.
体外研究：
ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL.ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells.
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