产品
编 号：F743046
分子式：C24H28Cl2N6O8
分子量：599.42
分子式：C24H28Cl2N6O8
分子量：599.42
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CAS No: 1196994-12-3
产品详情
生物活性：
ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect.
体内研究：
ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect.Animal Model:Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)
Dosage:1-100 mg/kg
Administration:Subcutaneous injection
Result:Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
体外研究：
ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils.ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils.
ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect.
体内研究：
ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect.Animal Model:Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)
Dosage:1-100 mg/kg
Administration:Subcutaneous injection
Result:Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
体外研究：
ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils.ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils.
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