产品
编 号：F743031
分子式：C31H46N2O8
分子量：574.71
分子式：C31H46N2O8
分子量：574.71
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1194396-71-8
产品详情
生物活性：
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma.
体内研究：
Bimatoprost grenod shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension.Bimatoprost grenod (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits.Bimatoprost grenod (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing.Animal Model:New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection
Dosage:0.14%
Administration:Instillation; 0.14% 30 μL; once
Result:Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma.
体内研究：
Bimatoprost grenod shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension.Bimatoprost grenod (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits.Bimatoprost grenod (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing.Animal Model:New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection
Dosage:0.14%
Administration:Instillation; 0.14% 30 μL; once
Result:Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备