产品
编 号:F743018
分子式:C69H93ClN16O19S2
分子量:1550.16
产品类型
结构图
CAS No: 1192362-32-5
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产品详情
生物活性:
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis.
体外研究:
177Lu-DOTA-LM3 是耐受的。177Lu-DOTA-LM3 主要存在于全身、肾脏、脾脏和转移灶中,导致器官和肿瘤平均吸收剂量较高。