产品
编 号：F742946
分子式：C21H27Cl2N3O2
分子量：424.36
分子式：C21H27Cl2N3O2
分子量：424.36
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CAS No: 1186049-44-4
产品详情
生物活性：
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72?μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.
体内研究：
DDO-02005 (0.1, 1, 3, 9 mg/kg; IV, single dosage) effectively combat the arrhythmogenic toxicity of aconitine in rats.Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats.IV (1 mg/kg) PO (1.25 mg/kg)
t1/2 (h)3.23?±?1.076.25?±?2.40
Cmax (μg/L)90.23?±?28.831.27?±?0.40
AUC0-t (μg/L·h)178.42?±?39.334.41?±?0.69
CL (L/h/kg)5.83?±?1.4436.51?±?2.54
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72?μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.
体内研究：
DDO-02005 (0.1, 1, 3, 9 mg/kg; IV, single dosage) effectively combat the arrhythmogenic toxicity of aconitine in rats.Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats.IV (1 mg/kg) PO (1.25 mg/kg)
t1/2 (h)3.23?±?1.076.25?±?2.40
Cmax (μg/L)90.23?±?28.831.27?±?0.40
AUC0-t (μg/L·h)178.42?±?39.334.41?±?0.69
CL (L/h/kg)5.83?±?1.4436.51?±?2.54
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