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编 号:F742818
分子式:C29H23ClN4O3
分子量:510.97
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生物活性:
Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity.

体外研究:
Duocarmycin analog-2 (72 h) has anti-proliferative activity with IC50 values of 0.001, 0.002, 0.002, 0.004, 0.009, 0.01, 0.015, 0.019, 0.019, 0.019, 0.02, 0.04, and 0.068 nM for DU4475, SET2, HCT 16, A2780, MDA MB468, LNCaP, LS174T, CCRF-CEM, COLO205, H2087, H661, A549, and MCD MB231 cells, respectively.
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