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编 号：F742750
分子式：C23H32O7S
分子量：452.56
分子式：C23H32O7S
分子量：452.56
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CAS No: 1152425-66-5
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生物活性：
Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC50?of?2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM).
体内研究：
SGLT2 inhibition with Luseogliflozin (10 mg/kg/daily; oral gavage) significantly ameliorates hyperglycaemia, but not hyperinsulinaemia, in the OSI-906(45 mg/kg)-treated mice. Luseogliflozin ameliorates hyperglycaemia induced by OSI-906.Animal Model:C57BL/6J male mice aged 8 weeks old
Dosage:10 mg/kg/daily
Administration:Oral gavage; for 7 days between 08:00 and 09:00 hours
Result:Treatment significantly ameliorated the OSI-906 (45 mg/kg)-induced hyperglycaemia.
体外研究：
Luseogliflozin can increase beta cell proliferation through the activation of the FoxM1/PLK1/CENP-A pathway via humoral factors thats act in an insulin/IGF-1 receptor-independent manner. Luseogliflozin increases beta cell proliferation in OSI-906-treated mice.
Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC50?of?2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM).
体内研究：
SGLT2 inhibition with Luseogliflozin (10 mg/kg/daily; oral gavage) significantly ameliorates hyperglycaemia, but not hyperinsulinaemia, in the OSI-906(45 mg/kg)-treated mice. Luseogliflozin ameliorates hyperglycaemia induced by OSI-906.Animal Model:C57BL/6J male mice aged 8 weeks old
Dosage:10 mg/kg/daily
Administration:Oral gavage; for 7 days between 08:00 and 09:00 hours
Result:Treatment significantly ameliorated the OSI-906 (45 mg/kg)-induced hyperglycaemia.
体外研究：
Luseogliflozin can increase beta cell proliferation through the activation of the FoxM1/PLK1/CENP-A pathway via humoral factors thats act in an insulin/IGF-1 receptor-independent manner. Luseogliflozin increases beta cell proliferation in OSI-906-treated mice.
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