产品
编 号：F742684
分子式：C29H31NO8
分子量：521.56
分子式：C29H31NO8
分子量：521.56
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1139253-73-8
产品详情
生物活性：
Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML.
体内研究：
Rohinitib (0.75 and 1.0 mg/kg; s.c. once daily for 5 consecutive days until mice get moribund) shows anti-AML effects in vivo.Animal Model:Female NSG mice with AML xenografts generated by intravenous injections of MOLM-13 cells
Dosage:0.75 and 1.0 mg/kg
Administration:Subcutaneous injection; 0.75 and 1.0 mg/kg once daily 5 days a week until mice get moribund
Result:Significantly reduced the leukemia burden, circulating and BM leukemic human CD45+ cells. Dose-dependently prolonged the survival rate of mice.
体外研究：
Rohinitib (6.25-50 nM; 72 h) induces cell apoptosis of AML cell lines and FLT3-ITD-positive AML cell lines.Primary AML cells is more sensitive to Rohinitib (25 nM; 72 h) than normal bone marrow (BM) and FLT3-ITD-positive cells is more sensitive to Rohinitib than FLT3 wild-type AML cells.
Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML.
体内研究：
Rohinitib (0.75 and 1.0 mg/kg; s.c. once daily for 5 consecutive days until mice get moribund) shows anti-AML effects in vivo.Animal Model:Female NSG mice with AML xenografts generated by intravenous injections of MOLM-13 cells
Dosage:0.75 and 1.0 mg/kg
Administration:Subcutaneous injection; 0.75 and 1.0 mg/kg once daily 5 days a week until mice get moribund
Result:Significantly reduced the leukemia burden, circulating and BM leukemic human CD45+ cells. Dose-dependently prolonged the survival rate of mice.
体外研究：
Rohinitib (6.25-50 nM; 72 h) induces cell apoptosis of AML cell lines and FLT3-ITD-positive AML cell lines.Primary AML cells is more sensitive to Rohinitib (25 nM; 72 h) than normal bone marrow (BM) and FLT3-ITD-positive cells is more sensitive to Rohinitib than FLT3 wild-type AML cells.
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