产品
编 号：F742673
分子式：C23H30N2O6
分子量：430.49
分子式：C23H30N2O6
分子量：430.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 113594-64-2
产品详情
生物活性：
KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent.
体内研究：
KB-5492 (200?mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.Animal Model:Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage
Dosage:200?mg/kg
Administration:Oral gavage
Result:Reduced the lesion length as compared with the control.Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
体外研究：
KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner.KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.
KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent.
体内研究：
KB-5492 (200?mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.Animal Model:Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage
Dosage:200?mg/kg
Administration:Oral gavage
Result:Reduced the lesion length as compared with the control.Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
体外研究：
KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner.KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.
产品资料
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