产品
编 号：F742640
分子式：C24H32KN3O8S
分子量：561.69
分子式：C24H32KN3O8S
分子量：561.69
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1132940-31-8
产品详情
生物活性：
ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM).
体内研究：
ABT-072 (5 and/or 30 mg/kg; i.v. or p.o.) (potassium trihydrate) shows good PK properties.ABT-072 (2.5 and/or 30 mg/kg; i.v. or p.o.) (potassium trihydrate) shows low plasma clearance and high oral bioavailability.Animal Model:Rats
Dosage:5 and/or 30 mg/kg (Pharmacokinetic Analysis)
Administration:I.v. or p.o.
Result:Showed good PK properties.
Animal Model:Dog
Dosage:2.5 or 30 mg/kg (Pharmacokinetic Analysis)
Administration:I.v. or p.o.
Result:Showed low plasma clearance and high oral bioavailability.
体外研究：
ABT-072 (potassium trihydrate) is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases.
ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM).
体内研究：
ABT-072 (5 and/or 30 mg/kg; i.v. or p.o.) (potassium trihydrate) shows good PK properties.ABT-072 (2.5 and/or 30 mg/kg; i.v. or p.o.) (potassium trihydrate) shows low plasma clearance and high oral bioavailability.Animal Model:Rats
Dosage:5 and/or 30 mg/kg (Pharmacokinetic Analysis)
Administration:I.v. or p.o.
Result:Showed good PK properties.
Animal Model:Dog
Dosage:2.5 or 30 mg/kg (Pharmacokinetic Analysis)
Administration:I.v. or p.o.
Result:Showed low plasma clearance and high oral bioavailability.
体外研究：
ABT-072 (potassium trihydrate) is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases.
产品资料
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