产品
编 号：F742464
分子式：C15H14N2O3S
分子量：302.35
分子式：C15H14N2O3S
分子量：302.35
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CAS No: 109310-99-8
产品详情
生物活性：
Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies.
体外研究：
Antibacterial agent 122 (compound 15) (25-200 μM, 24 h) inhibits M. tuberculosis H37Rv with the MIC50 value of 5.9 μM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 8.1μM.Antibacterial agent 122 (compound 15) (25-200 μM) acts on NO scavenging with an IC50 value of 184.2 μM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 μM.Antibacterial agent 122 (compound 15) (0-200 μM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC50 values of 28.4 μM and 47.9 μM, respectively.Antibacterial agent 122 (compound 15) (25-100 μM, 4 days) inhibits M. tuberculosis M299 with an MIC50 value of 24.7 μM.
Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies.
体外研究：
Antibacterial agent 122 (compound 15) (25-200 μM, 24 h) inhibits M. tuberculosis H37Rv with the MIC50 value of 5.9 μM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 8.1μM.Antibacterial agent 122 (compound 15) (25-200 μM) acts on NO scavenging with an IC50 value of 184.2 μM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 μM.Antibacterial agent 122 (compound 15) (0-200 μM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC50 values of 28.4 μM and 47.9 μM, respectively.Antibacterial agent 122 (compound 15) (25-100 μM, 4 days) inhibits M. tuberculosis M299 with an MIC50 value of 24.7 μM.
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