产品
编 号：F742400
分子式：C184H296N57O55PS7
分子量：4442.1
分子式：C184H296N57O55PS7
分子量：4442.1
产品类型
规格
价格
是否有货
结构图
CAS No: 1081110-69-1
产品详情
生物活性：
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
体内研究：
Dalazatide (ShK-186) (100 μg/kg; s.c.; once) 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活。Animal Model:Lewis rats rats, delayed-type hypersensitivity (DTH) model
Dosage:100 μg/kg
Administration:Subcutaneous injection, once
Result:Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.
体外研究：
Dalazatide (ShK-186) (0-1000 pM) 以剂量依赖的方式阻断卵巢特异性 GFP+ 效应记忆 T (Tem) 细胞中的 Kv1.3 电流，Kd 为 65 ± 5 pM。Dalazatide (0-100 nM; 3 days) 以剂量依赖的方式抑制 CCR7? T 细胞增殖。Dalazatide (100 nM; 30 min) 通过抑制钙信号通路固定炎症部位的效应记忆 T (Tem) 细胞，从而阻止 β1 整合素激活。
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
体内研究：
Dalazatide (ShK-186) (100 μg/kg; s.c.; once) 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活。Animal Model:Lewis rats rats, delayed-type hypersensitivity (DTH) model
Dosage:100 μg/kg
Administration:Subcutaneous injection, once
Result:Reduced DTH at all time points compared to rats given saline injections. Suppressed the proliferation of the Tem cells.
体外研究：
Dalazatide (ShK-186) (0-1000 pM) 以剂量依赖的方式阻断卵巢特异性 GFP+ 效应记忆 T (Tem) 细胞中的 Kv1.3 电流，Kd 为 65 ± 5 pM。Dalazatide (0-100 nM; 3 days) 以剂量依赖的方式抑制 CCR7? T 细胞增殖。Dalazatide (100 nM; 30 min) 通过抑制钙信号通路固定炎症部位的效应记忆 T (Tem) 细胞，从而阻止 β1 整合素激活。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备