产品
编 号：F742365
分子量：4967
分子量：4967
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1072874-90-8
产品详情
生物活性：
Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection.
体内研究：
Miravirsen (SPC-3649; 2.5-25 mg/kg; i.v.; daily, for 3 d) inhibits miR-122 activity in mice.Animal Model:NMRI female mice (27 g)
Dosage:2.5, 6.25, 12.5, and 25 mg/kg
Administration:Intravenous injection; daily, for 3 days
Result:Inhibited miR-122 activity in a dose-dependent manner.
体外研究：
Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122. Miravirsen binds to the stem-loop structure of pri- and pre-miR-122 with nanomolar affinity, and inhibits both Dicer- and Drosha-mediated processing of miR-122 precursors.
Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection.
体内研究：
Miravirsen (SPC-3649; 2.5-25 mg/kg; i.v.; daily, for 3 d) inhibits miR-122 activity in mice.Animal Model:NMRI female mice (27 g)
Dosage:2.5, 6.25, 12.5, and 25 mg/kg
Administration:Intravenous injection; daily, for 3 days
Result:Inhibited miR-122 activity in a dose-dependent manner.
体外研究：
Miravirsen is thought to work mainly by hybridizing to mature miR-122 and blocking its interaction with HCV RNA, its target sequence is also present in pri- and pre-miR-122. Miravirsen binds to the stem-loop structure of pri- and pre-miR-122 with nanomolar affinity, and inhibits both Dicer- and Drosha-mediated processing of miR-122 precursors.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备