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编 号：F742148
分子式：C27H40N4O7
分子量：532.63
分子式：C27H40N4O7
分子量：532.63
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CAS No: 1032595-77-9
产品详情
生物活性：
Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research.
体内研究：
Quercetin 3-(6″-caffeoylsophoroside) (50，100，500，1000，2000 mg/kg，口服灌胃) 在 SD 大鼠急性口服毒性试验中显示安全性，可用于抗糖尿病研究。Quercetin 3-(6″-caffeoylsophoroside) (125，250，500 mg/kg，口服灌胃) 通过减少氧化应激和抑制 α-淀粉酶改善了 SD 大鼠的 2 型糖尿病。Animal Model:FED HFD (45% fat) for 30 days to induce type 2 diabetes mellitus in SD rats
Dosage:125, 250, 500 mg/kg
Administration:Oral gavage (p.o.)
Result:Significantly decreased the blood glucose level, improved biochemical parameters as well as oxidative stress by reduction of lipid peroxidation, and increased high-density lipoproteins with dose of 500mg/kg. Enhanced activities of glutathione-s-transferase, glutathione, superoxide dismutase. Restored cellular architecture in the histopathological examination.
Animal Model:Acute oral toxicity in 8-week male SD rats
Dosage:50, 100, 500, 1000, and 2000 mg/kg
Administration:Oral gavage (p.o.)
Result:Safe for use in anti-diabetic research.
Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research.
体内研究：
Quercetin 3-(6″-caffeoylsophoroside) (50，100，500，1000，2000 mg/kg，口服灌胃) 在 SD 大鼠急性口服毒性试验中显示安全性，可用于抗糖尿病研究。Quercetin 3-(6″-caffeoylsophoroside) (125，250，500 mg/kg，口服灌胃) 通过减少氧化应激和抑制 α-淀粉酶改善了 SD 大鼠的 2 型糖尿病。Animal Model:FED HFD (45% fat) for 30 days to induce type 2 diabetes mellitus in SD rats
Dosage:125, 250, 500 mg/kg
Administration:Oral gavage (p.o.)
Result:Significantly decreased the blood glucose level, improved biochemical parameters as well as oxidative stress by reduction of lipid peroxidation, and increased high-density lipoproteins with dose of 500mg/kg. Enhanced activities of glutathione-s-transferase, glutathione, superoxide dismutase. Restored cellular architecture in the histopathological examination.
Animal Model:Acute oral toxicity in 8-week male SD rats
Dosage:50, 100, 500, 1000, and 2000 mg/kg
Administration:Oral gavage (p.o.)
Result:Safe for use in anti-diabetic research.
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