产品
编 号:F001168
分子式:C20H17NO5
分子量:351.35
产品类型
结构图
CAS No: 1001288-58-9
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产品详情
生物活性:
FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis. FT011 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究:
FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats.Animal Model:Seventy male Sprague Dawley (SD) rats (weighing 200-250 g)
Dosage:100 mg/kg
Administration:B.I.D., p.o. on day 7 after surgery, for 4 weeks
Result:Increased ejection fraction, fraction shortening and preload recruitable stroke work.