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编 号:F742120
分子式:C21H27N5O4S2
分子量:477.6
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生物活性:
Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications.

体外研究:
Cas9-IN-1 (compound 2) (200 and 500 μM; overnight) helps the E. coli selection strain to survive SpyCas9-induced killing.
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