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编 号：F742093
分子式：C14H13N3
分子量：223.27
分子式：C14H13N3
分子量：223.27
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CAS No: 102676-87-9
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生物活性：
Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..
体内研究：
Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole.Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect.Animal Model:SHHF rats
Dosage:0.24 and 1.2 mg/kg
Administration:Daily; oral
Result:Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
体外研究：
The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of Dexfadrostat.
Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..
体内研究：
Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole.Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect.Animal Model:SHHF rats
Dosage:0.24 and 1.2 mg/kg
Administration:Daily; oral
Result:Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
体外研究：
The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of Dexfadrostat.
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