产品
编 号:F742031
分子式:C24H22BrN3O5
分子量:512.35
产品类型
结构图
CAS No: 101982-51-8
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产品详情
生物活性:
NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.
体外研究:
NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression.NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving.