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编 号：F742017
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CAS No: 1018108-22-9
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生物活性：
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases.
体内研究：
SPC4061 (20 mg/kg first s.c.; and 5 mg/kg at day 7-28, once weekly for 4 weeks) produces a significant reduction in serum PCSK9 protein levels in monkey models.
体外研究：
SPC4061 reduces PCSK9 mRNA levels in treated cells.
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases.
体内研究：
SPC4061 (20 mg/kg first s.c.; and 5 mg/kg at day 7-28, once weekly for 4 weeks) produces a significant reduction in serum PCSK9 protein levels in monkey models.
体外研究：
SPC4061 reduces PCSK9 mRNA levels in treated cells.
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