产品
编 号：F741847
分子式：C27H43Cl2IN2
分子量：593.45
分子式：C27H43Cl2IN2
分子量：593.45
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 2904601-67-6
产品详情
生物活性：
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.
体内研究：
Aldometanib (oral; 0-10 mpk) 可降低瘦小鼠的血糖。Aldometanib (oral; 2-10 mpk; twice daily; for a week) 可降低血糖并减轻肥胖高血糖小鼠的脂肪肝。 Aldometanib 减轻脂肪肝和非酒精性脂肪性肝炎。 Aldometanib (oral; 2mpk; twice-daily; for a month) 减轻 NASH 小鼠的肝纤维化。Aldometanib (oral; 0-50 μM; 0-50 days) 可通过溶酶体途径延长 C. elegans 生命。Animal Model:Lean mice
Dosage:0-10 mpk
Administration:Oral
Result:Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.
Animal Model:Obese hyperglycaemic mice
Dosage:2-10 mpk
Administration:Oral, twice daily, for a week
Result:Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.
Animal Model:NASH mice
Dosage:2 mpk
Administration:Oral, twice-daily, for a month
Result:Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.
Animal Model:C. elegans
Dosage:0-50 μM
Administration:Oral, 0-50 days
Result:Promoted oxidative stress resistance and mitochondrial functions in C. elegans.
Animal Model:C57BL/6 mice
Dosage:100 μg/mL
Administration:Oral
Result:Extended lifespan, elevated NAD＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.
体外研究：
Aldometanib (0-1000 nM；2 小时) 通过阻止醛缩酶与 FBP 结合以产生假性饥饿信号来激活 AMPK。
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.
体内研究：
Aldometanib (oral; 0-10 mpk) 可降低瘦小鼠的血糖。Aldometanib (oral; 2-10 mpk; twice daily; for a week) 可降低血糖并减轻肥胖高血糖小鼠的脂肪肝。 Aldometanib 减轻脂肪肝和非酒精性脂肪性肝炎。 Aldometanib (oral; 2mpk; twice-daily; for a month) 减轻 NASH 小鼠的肝纤维化。Aldometanib (oral; 0-50 μM; 0-50 days) 可通过溶酶体途径延长 C. elegans 生命。Animal Model:Lean mice
Dosage:0-10 mpk
Administration:Oral
Result:Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.
Animal Model:Obese hyperglycaemic mice
Dosage:2-10 mpk
Administration:Oral, twice daily, for a week
Result:Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.
Animal Model:NASH mice
Dosage:2 mpk
Administration:Oral, twice-daily, for a month
Result:Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.
Animal Model:C. elegans
Dosage:0-50 μM
Administration:Oral, 0-50 days
Result:Promoted oxidative stress resistance and mitochondrial functions in C. elegans.
Animal Model:C57BL/6 mice
Dosage:100 μg/mL
Administration:Oral
Result:Extended lifespan, elevated NAD＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.
体外研究：
Aldometanib (0-1000 nM；2 小时) 通过阻止醛缩酶与 FBP 结合以产生假性饥饿信号来激活 AMPK。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备