产品
编 号：F741842
分子式：C19H26N4O2S
分子量：374.5
分子式：C19H26N4O2S
分子量：374.5
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CAS No: 2890765-10-1
产品详情
生物活性：
PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity.
体内研究：
The pharmacokinetic parameters of PRMT6-IN-3(compound 25) in rat Parametersiv (2 mg/kg)po (10 mg/kg) Tmax (h)0.080.33T1/2 (h)1.461.63AUC(0-t)(ng*h/mL)661.50123.53MRT(0-t) (h)1.241.86Cmax (ng/mL)-88.32F (%)-3.73
体外研究：
PRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells. PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively.
PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity.
体内研究：
The pharmacokinetic parameters of PRMT6-IN-3(compound 25) in rat Parametersiv (2 mg/kg)po (10 mg/kg) Tmax (h)0.080.33T1/2 (h)1.461.63AUC(0-t)(ng*h/mL)661.50123.53MRT(0-t) (h)1.241.86Cmax (ng/mL)-88.32F (%)-3.73
体外研究：
PRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells. PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively.
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