产品
编 号：F741840
分子式：C23H24FNO4S
分子量：429.5
分子式：C23H24FNO4S
分子量：429.5
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2883495-39-2
产品详情
生物活性：
Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis.
体外研究：
Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-100 μM; ) inhibits some cancer cells growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 μM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.Enpp/Carbonic anhydrase-IN-2 (0-2 μM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM.Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 μM) induces apoptosis in a dose-dependent manner at K-562 cells.
Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis.
体外研究：
Enpp/Carbonic anhydrase-IN-2 (compound 1i) (0-100 μM; ) inhibits some cancer cells growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 μM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.Enpp/Carbonic anhydrase-IN-2 (0-2 μM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM.Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 μM) induces apoptosis in a dose-dependent manner at K-562 cells.
产品资料
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