产品
编 号：F741824
分子式：C25H26Cl2N2O5S
分子量：537.46
分子式：C25H26Cl2N2O5S
分子量：537.46
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2823308-89-8
产品详情
生物活性：
PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
体内研究：
PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine.PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg.PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1.PARP1-IN-5 dihydrochloride can upregulate the expression of γ-H2AX and decrease the expression of PAR.Animal Model:Mice
Dosage:1000 mg/kg
Administration:P.o.
Result:There was no significant difference in the body weight and blood routine.
Animal Model:Mice
Dosage:25 and 50 mg/kg
Administration:P.o.; 12 days
Result:Significantly enhanced the inhibitory effect of CBP on A549 cells at 50 mg/kg.
Animal Model:Male Sprague?Dawley (SD) rats
Dosage:50 mg/kg (Pharmacokinetic Analysis)
Administration:P.o.
Result:Positively correlated with the expression of PARP-1.
体外研究：
PARP1-IN-5 dihydrochloride (0.1~10 μM; A549 cells) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 dihydrochloride (0.1~10 μM; SK-OV-3 cells) decreases the expressions of MCM2-7. PARP1-IN-5 dihydrochloride (0.1~320 μM; A549 cells) has little cytotoxic effects on A549 cells. PARP1-IN-5 dihydrochloride (SK-OV-3 cells) can significantly decrease the PAR level.PARP1-IN-5 dihydrochloride exerts antitumor effects through PARP-1. PARP1-IN-5 dihydrochloride could increase the γ-H2AX expression.
PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
体内研究：
PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine.PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg.PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1.PARP1-IN-5 dihydrochloride can upregulate the expression of γ-H2AX and decrease the expression of PAR.Animal Model:Mice
Dosage:1000 mg/kg
Administration:P.o.
Result:There was no significant difference in the body weight and blood routine.
Animal Model:Mice
Dosage:25 and 50 mg/kg
Administration:P.o.; 12 days
Result:Significantly enhanced the inhibitory effect of CBP on A549 cells at 50 mg/kg.
Animal Model:Male Sprague?Dawley (SD) rats
Dosage:50 mg/kg (Pharmacokinetic Analysis)
Administration:P.o.
Result:Positively correlated with the expression of PARP-1.
体外研究：
PARP1-IN-5 dihydrochloride (0.1~10 μM; A549 cells) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 dihydrochloride (0.1~10 μM; SK-OV-3 cells) decreases the expressions of MCM2-7. PARP1-IN-5 dihydrochloride (0.1~320 μM; A549 cells) has little cytotoxic effects on A549 cells. PARP1-IN-5 dihydrochloride (SK-OV-3 cells) can significantly decrease the PAR level.PARP1-IN-5 dihydrochloride exerts antitumor effects through PARP-1. PARP1-IN-5 dihydrochloride could increase the γ-H2AX expression.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备