产品
编 号:F741799
分子式:C18H13ClN4O
分子量:336.78
产品类型
结构图
CAS No: 2765453-51-6
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生物活性:
TTBK1-IN-2 (compound 29) is a potent Tau-Tubulin kinase (TTBK1) inhibitor with IC50s of 0.24 and 4.22 μM, respectively. TTBK1-IN-2 reveals good brain penetration in vivo and is able to reduce TDP-43 phosphorylation not only in cell cultures but also in the spinal cord of transgenic TDP-43 mice.