产品
编 号：F741745
分子式：C32H37N3O4S
分子量：559.72
分子式：C32H37N3O4S
分子量：559.72
产品类型
规格
价格
是否有货
结构图
CAS No: 2740807-77-4
产品详情
生物活性：
BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.
体内研究：
BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) results in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.BI 703704 is effective in elevating renal cGMP levels in a dose-dependent manner and in slowing the progression of diabetic nephropathy in an oxidative stress milieu.Animal Model:Fifty-eight male ZSF1 rats (12-13 weeks)
Dosage:0.3, 1, 3, or 10 mg/kg
Administration:Food intake; daily for 15 weeks
Result:Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.
BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.
体内研究：
BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) results in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.BI 703704 is effective in elevating renal cGMP levels in a dose-dependent manner and in slowing the progression of diabetic nephropathy in an oxidative stress milieu.Animal Model:Fifty-eight male ZSF1 rats (12-13 weeks)
Dosage:0.3, 1, 3, or 10 mg/kg
Administration:Food intake; daily for 15 weeks
Result:Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备