产品
编 号：F741692
分子式：C26H34F3N5O3
分子量：521.58
分子式：C26H34F3N5O3
分子量：521.58
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 2639957-39-2
产品详情
生物活性：
Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity.
体内研究：
Exarafenib (RAF/KIN_2787；3-30 mg/kg；口服灌胃；每天两次；29 天) 可有效对抗体内 BRAFmut 和 NRASmut 人类黑色素瘤异种移植物。Animal Model:BALB/c nude mice xenograft models of BRAF and NRAS-mutant melanoma
Dosage:3, 5, 10, 20, 30 mg/kg
Administration:Orally; twice daily (BID); 29 days
Result:Was effective against BRAFmut & NRASmut human melanoma xenografts in vivo.
体外研究：
Exarafenib (RAF/KIN_2787；1-10000 nM；24 小时) 抑制 RAF 依赖性黑色素瘤细胞系生长。Exarafenib 可抑制 RAF 依赖性黑色素瘤细胞系中的 MAPK 信号传导。
Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity.
体内研究：
Exarafenib (RAF/KIN_2787；3-30 mg/kg；口服灌胃；每天两次；29 天) 可有效对抗体内 BRAFmut 和 NRASmut 人类黑色素瘤异种移植物。Animal Model:BALB/c nude mice xenograft models of BRAF and NRAS-mutant melanoma
Dosage:3, 5, 10, 20, 30 mg/kg
Administration:Orally; twice daily (BID); 29 days
Result:Was effective against BRAFmut & NRASmut human melanoma xenografts in vivo.
体外研究：
Exarafenib (RAF/KIN_2787；1-10000 nM；24 小时) 抑制 RAF 依赖性黑色素瘤细胞系生长。Exarafenib 可抑制 RAF 依赖性黑色素瘤细胞系中的 MAPK 信号传导。
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