产品
编 号：F741677
分子式：C25H34N4O5S2
分子量：534.69
分子式：C25H34N4O5S2
分子量：534.69
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2600559-20-2
产品详情
生物活性：
KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
体内研究：
KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice.IP (100 mg/kg)
Cmax (μM)12.6
AUC0-24 (μM·h)147
C24h (μM)2.9
PPB (fu)0.007
Animal Model:Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)
Dosage:100 mg/kg
Administration:i.p., single
Result:Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
体内研究：
KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice.IP (100 mg/kg)
Cmax (μM)12.6
AUC0-24 (μM·h)147
C24h (μM)2.9
PPB (fu)0.007
Animal Model:Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)
Dosage:100 mg/kg
Administration:i.p., single
Result:Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
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