产品
编 号：F741674
分子式：C34H27NO5S2
分子量：593.71
分子式：C34H27NO5S2
分子量：593.71
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
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10mg
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询价
结构图
CAS No: 2595314-46-6
产品详情
生物活性：
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.
体内研究：
WEHI-9625 表明，在早期阶段阻断细胞凋亡既有利又具有药理学上的易处理性。
体外研究：
WEHI-9625 (0-10 μM；Mcl1?/?Bax?/? MEF 细胞) 处理可防止 BAK 介导的细胞死亡并有效在 Bax?/? 而非 Bak?/? 细胞中抑制 BIM BH3 诱导的线粒体膜电位的损失。
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.
体内研究：
WEHI-9625 表明，在早期阶段阻断细胞凋亡既有利又具有药理学上的易处理性。
体外研究：
WEHI-9625 (0-10 μM；Mcl1?/?Bax?/? MEF 细胞) 处理可防止 BAK 介导的细胞死亡并有效在 Bax?/? 而非 Bak?/? 细胞中抑制 BIM BH3 诱导的线粒体膜电位的损失。
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