产品
编 号：F741669
分子式：C29H27ClN4O2
分子量：499
分子式：C29H27ClN4O2
分子量：499
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CAS No: 2582757-69-3
产品详情
生物活性：
Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
体内研究：
Aβ42-IN-1 (orally adminstation; 30 mg/kg)shows a good pharmacokinetic profile in mice, significantly reduces Aβ42 levels in the brain and plasma, by 36% and 66%, respectively. while the brain/plasma ratio of 1v is slightly lower than that of 1a.Animal Model:8- week-old male ddY mice
Dosage:30 mg/kg
Administration:Orally adminstation; 30 mg/kg
Result:Reduced Aβ42 levels in the brain and plasma, by 36% and 66%, respectively.
Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
体内研究：
Aβ42-IN-1 (orally adminstation; 30 mg/kg)shows a good pharmacokinetic profile in mice, significantly reduces Aβ42 levels in the brain and plasma, by 36% and 66%, respectively. while the brain/plasma ratio of 1v is slightly lower than that of 1a.Animal Model:8- week-old male ddY mice
Dosage:30 mg/kg
Administration:Orally adminstation; 30 mg/kg
Result:Reduced Aβ42 levels in the brain and plasma, by 36% and 66%, respectively.
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