产品
编 号：F741664
分子式：C31H39N9O6S
分子量：665.76
分子式：C31H39N9O6S
分子量：665.76
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2574390-27-3
产品详情
生物活性：
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
体内研究：
MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls in NOD-scid IL2Rgnull (NSG) mice.MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice.
体外研究：
MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively.MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, VSV-SARS CoV-2 chimera calu-3 and MERS VSV pseudotype calu-3 with the EC50 values of 74, 0.43 and 0.87 nM, respectively.
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
体内研究：
MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls in NOD-scid IL2Rgnull (NSG) mice.MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice.
体外研究：
MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively.MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, VSV-SARS CoV-2 chimera calu-3 and MERS VSV pseudotype calu-3 with the EC50 values of 74, 0.43 and 0.87 nM, respectively.
产品资料
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