产品
编 号：F741634
分子式：C24H21ClN2O3
分子量：420.89
分子式：C24H21ClN2O3
分子量：420.89
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2493239-46-4
产品详情
生物活性：
AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect.
体内研究：
AMPK activator 4 (100 mg/kg; Intragastrical administration; daily for 9 weeks) shows anti-hyperglycemic effect.Animal Model:db/db mice (5-week old)
Dosage:100 mg/kg
Administration:Intragastrical administration; daily for 9 weeks
Result:Significantly lowered the fasting blood glucose in db/db mice (2-6 weeks). Significantly improved insulin resistance in db/db mice (for 9 weeks). The body weight and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (two markers of liver injury) were not significantly affected.
体外研究：
AMPK activator 4 (compound B10) (0-20 μM; 12-24 hours) induces phosphorylation of AMPK and its downstream protein ACC.AMPK activator 4-mediated AMPK phosphorylation requires LKB1.AMPK activator 4 slight decreases the viability of HepG2 cells after 72 hours of treatment at 10-20 μM.
AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect.
体内研究：
AMPK activator 4 (100 mg/kg; Intragastrical administration; daily for 9 weeks) shows anti-hyperglycemic effect.Animal Model:db/db mice (5-week old)
Dosage:100 mg/kg
Administration:Intragastrical administration; daily for 9 weeks
Result:Significantly lowered the fasting blood glucose in db/db mice (2-6 weeks). Significantly improved insulin resistance in db/db mice (for 9 weeks). The body weight and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (two markers of liver injury) were not significantly affected.
体外研究：
AMPK activator 4 (compound B10) (0-20 μM; 12-24 hours) induces phosphorylation of AMPK and its downstream protein ACC.AMPK activator 4-mediated AMPK phosphorylation requires LKB1.AMPK activator 4 slight decreases the viability of HepG2 cells after 72 hours of treatment at 10-20 μM.
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