产品
编 号：F741594
分子式：C23H24N6O3
分子量：432.48
分子式：C23H24N6O3
分子量：432.48
产品类型
规格
价格
是否有货
结构图
CAS No: 2438637-64-8
产品详情
生物活性：
GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean Kiapp values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively.
体内研究：
GNE684 also had no impact on overall survival or tumor growth in the KPP or KPR (LSL-Kras G12D/+; p16/p19 fl/wt ; Trp53 R270H/wt ; Pdx1-cre) PDAC models.GNE684 (50mg/kg; p.o. twice daily) inhibits colitis and ileitis caused by NEMO deficiency in intestinal epithelial cells (IECs).Animal Model:Nemofl/fl Villin.creERT2 mice (NEMO IEC-KO)
Dosage:50 mg/kg
Administration:Oral administration; twice daily; from days 2–6 treated with tamoxifen
Result:Almost completely protected the NEMO-deficient intestines from colitis and ileitis.
体外研究：
GNE684 (20 μM; 20 hours) inhibits RIP1 kinase driven cell death effectively in several human and mouse cell lines.GNE684 (20 μM; 0-60 minutes) disrupts TBZ (2 μM BV6, 20 ng/ml TNF, 20 μM zVAD)-induced RIP1 autophosphorylation, interactions between RIP1 and RIP3, RIP3 autophosphorylation, and phosphorylation of MLKL by RIP3.
GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean Kiapp values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively.
体内研究：
GNE684 also had no impact on overall survival or tumor growth in the KPP or KPR (LSL-Kras G12D/+; p16/p19 fl/wt ; Trp53 R270H/wt ; Pdx1-cre) PDAC models.GNE684 (50mg/kg; p.o. twice daily) inhibits colitis and ileitis caused by NEMO deficiency in intestinal epithelial cells (IECs).Animal Model:Nemofl/fl Villin.creERT2 mice (NEMO IEC-KO)
Dosage:50 mg/kg
Administration:Oral administration; twice daily; from days 2–6 treated with tamoxifen
Result:Almost completely protected the NEMO-deficient intestines from colitis and ileitis.
体外研究：
GNE684 (20 μM; 20 hours) inhibits RIP1 kinase driven cell death effectively in several human and mouse cell lines.GNE684 (20 μM; 0-60 minutes) disrupts TBZ (2 μM BV6, 20 ng/ml TNF, 20 μM zVAD)-induced RIP1 autophosphorylation, interactions between RIP1 and RIP3, RIP3 autophosphorylation, and phosphorylation of MLKL by RIP3.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备