产品
编 号：F741592
分子式：C24H24ClN3O
分子量：405.92
分子式：C24H24ClN3O
分子量：405.92
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2436760-79-9
产品详情
生物活性：
GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
体外研究：
GSK690 (1-10 μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
体外研究：
GSK690 (1-10 μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
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