产品
编 号：F741568
分子式：C24H25F3N4O
分子量：442.48
分子式：C24H25F3N4O
分子量：442.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2415206-22-1
产品详情
生物活性：
TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.
体内研究：
TRPA1-IN-2 (90 mg/kg；小鼠腹腔注射；大鼠腹腔注射 30 mg/kg；100 mg/kg；口服) 显示出抗炎活性。Animal Model:16-18 g, female BABL/c mice
Dosage:90 mg/kg
Administration:I.p.; for 7 days
Result:Reduced the total number of white blood cells and eosinophils in BALF.
Animal Model:160-180 g, SD male rats (asthmatic rats)
Dosage:30 mg/kg
Administration:I.p.; for 7 days
Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.
TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.
体内研究：
TRPA1-IN-2 (90 mg/kg；小鼠腹腔注射；大鼠腹腔注射 30 mg/kg；100 mg/kg；口服) 显示出抗炎活性。Animal Model:16-18 g, female BABL/c mice
Dosage:90 mg/kg
Administration:I.p.; for 7 days
Result:Reduced the total number of white blood cells and eosinophils in BALF.
Animal Model:160-180 g, SD male rats (asthmatic rats)
Dosage:30 mg/kg
Administration:I.p.; for 7 days
Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.
产品资料
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