产品
编 号:F741566
分子式:C25H22ClN5O5
分子量:507.93
产品类型
结构图
CAS No: 2414285-40-6
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产品详情
生物活性:
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect.
体内研究:
Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg).