产品
编 号：F741563
分子式：C31H39N5O7
分子量：593.67
分子式：C31H39N5O7
分子量：593.67
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CAS No: 2412965-59-2
产品详情
生物活性：
SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively.
体内研究：
SARS-CoV-2-IN-1 (3 mg/kg; subcutaneous) shows the Cmax is 126.2 ng/mL. The mean residence time for SARS-CoV-2-IN-1 is extended to 2.7 hours and the plasma half-life in CD-1 mice is 1.8 hour.
体外研究：
In a SARS-CoV replicon, SARS-CoV-2-IN-1 (compound 13b) inhibits RNA replication with an EC50of 1.75 μM. In human Calu3 cells infected with the novel coronavirus, SARS-CoV-2, SARS-CoV-2-IN1 shows an EC50 of 4-5 μM.
SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively.
体内研究：
SARS-CoV-2-IN-1 (3 mg/kg; subcutaneous) shows the Cmax is 126.2 ng/mL. The mean residence time for SARS-CoV-2-IN-1 is extended to 2.7 hours and the plasma half-life in CD-1 mice is 1.8 hour.
体外研究：
In a SARS-CoV replicon, SARS-CoV-2-IN-1 (compound 13b) inhibits RNA replication with an EC50of 1.75 μM. In human Calu3 cells infected with the novel coronavirus, SARS-CoV-2, SARS-CoV-2-IN1 shows an EC50 of 4-5 μM.
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