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编 号:F741535
分子式:C22H27ClFN5O3
分子量:463.93
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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生物活性:
PF-07220060 (CDK4/6-IN-6; example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

体外研究:
PF-07220060 (CDK4/6-IN-6; example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells.
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