产品
编 号:F741535
分子式:C22H27ClFN5O3
分子量:463.93
产品类型
结构图
CAS No: 2380321-51-5
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产品详情
生物活性:
PF-07220060 (CDK4/6-IN-6; example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
体外研究:
PF-07220060 (CDK4/6-IN-6; example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells.