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编 号:F741480
分子式:C27H31ClN4O2
分子量:479.01
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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生物活性:
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor.

体外研究:
UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth.UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression.
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