产品
编 号：F741476
分子式：C25H19ClF4N2O2
分子量：490.88
分子式：C25H19ClF4N2O2
分子量：490.88
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 2259624-71-8
产品详情
生物活性：
STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.
体内研究：
STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life.Animal Model:Balb/c mice (n=3)
Dosage:5 or 10 mpk
Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.RouteDOSE (mpk) AUC (ng/mL*h)T1/2(h) Cmax(ng/mL) Vd(mL/kg) F(%)
IV512151.4118672689NA
PO102090NA1723NA86
体外研究：
STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.
体内研究：
STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life.Animal Model:Balb/c mice (n=3)
Dosage:5 or 10 mpk
Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.RouteDOSE (mpk) AUC (ng/mL*h)T1/2(h) Cmax(ng/mL) Vd(mL/kg) F(%)
IV512151.4118672689NA
PO102090NA1723NA86
体外研究：
STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
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