产品
编 号：F741466
分子式：C18H14N2O3
分子量：306.32
分子式：C18H14N2O3
分子量：306.32
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2250156-71-7
产品详情
生物活性：
MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer.
体内研究：
MEISi-2 (10?μM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content.MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF.Animal Model:4-6 week-old BALB/c mice
Dosage:10?μM/100?μL
Administration:Intraperitoneal injection, at day 1, day 4 and day 7
Result:Modulated HSC pool.
体外研究：
MEISi-2 does not significantly inhibit the PBX-Luc-reporter.MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal.MEISi-2 down-regulates MEIS target gene expression.MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
MEISi-2 is a selective inhibitor of MEIS, a key regulator of hematopoietic stem cell (HSC) self-renewal. MEISi-2 is developed for the research of cardiac injuries, hematopoiesis issues, bone marrow transplantations, and cancer.
体内研究：
MEISi-2 (10?μM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content.MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF.Animal Model:4-6 week-old BALB/c mice
Dosage:10?μM/100?μL
Administration:Intraperitoneal injection, at day 1, day 4 and day 7
Result:Modulated HSC pool.
体外研究：
MEISi-2 does not significantly inhibit the PBX-Luc-reporter.MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal.MEISi-2 down-regulates MEIS target gene expression.MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
产品资料
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