产品
编 号：F741459
分子式：C32H32N6O2
分子量：532.64
分子式：C32H32N6O2
分子量：532.64
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2244987-03-7
产品详情
生物活性：
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12.
体外研究：
CDK12-IN-2 在低亚微摩尔浓度下抑制 SK-BR-3 细胞中 CTD Ser2 的磷酸化，它抑制 C-末端结构域 ser2 磷酸化，IC50 为 185 nM。CDK12-IN-2 对 SK-BR-3 细胞具有生长抑制作用，IC50 为 0.8 μM。CDK12-IN- 2 显示 CDK12 抑制的时间依赖性，CDK12-IN-2 的 IC50 值分别为 0.0078 μM、0.042 μM、0.057 μM 和 0.059 μM，分别为 0h、1h、2h 和 5h。
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12.
体外研究：
CDK12-IN-2 在低亚微摩尔浓度下抑制 SK-BR-3 细胞中 CTD Ser2 的磷酸化，它抑制 C-末端结构域 ser2 磷酸化，IC50 为 185 nM。CDK12-IN-2 对 SK-BR-3 细胞具有生长抑制作用，IC50 为 0.8 μM。CDK12-IN- 2 显示 CDK12 抑制的时间依赖性，CDK12-IN-2 的 IC50 值分别为 0.0078 μM、0.042 μM、0.057 μM 和 0.059 μM，分别为 0h、1h、2h 和 5h。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备