产品
编 号：F741453
分子式：C15H17N3O3S
分子量：319.38
分子式：C15H17N3O3S
分子量：319.38
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2242480-48-2
产品详情
生物活性：
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity.
体外研究：
VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively.VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity.VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro.VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells.The exposure of larvae to 1 or 10 μM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh.
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity.
体外研究：
VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively.VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity.VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro.VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells.The exposure of larvae to 1 or 10 μM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh.
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