产品
编 号：F741401
分子式：C22H18N4OS
分子量：386.47
分子式：C22H18N4OS
分子量：386.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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结构图
CAS No: 2170170-27-9
产品详情
生物活性：
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS).
体内研究：
SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3?mM, 流速 0.15 μL/h) 改善 ALS 模型小鼠的 ALS 病理。Animal Model:ALS model C57BL/6 mice
Dosage:3?mM, flow rate 0.15?μL/h
Administration:intracerebroventrical injection
Result:Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement).
体外研究：
SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) 以剂量依赖性方式抑制 SOD1-Derlin-1 相互作用。
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS).
体内研究：
SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3?mM, 流速 0.15 μL/h) 改善 ALS 模型小鼠的 ALS 病理。Animal Model:ALS model C57BL/6 mice
Dosage:3?mM, flow rate 0.15?μL/h
Administration:intracerebroventrical injection
Result:Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement).
体外研究：
SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) 以剂量依赖性方式抑制 SOD1-Derlin-1 相互作用。
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